High doses of MDMA Canada can affect the body’s ability to regulate temperature. This can lead to a spike in body temperature that can occasionally result in liver, kidney, or heart failure or even death.
In addition, because MDMA Canada can promote trust and closeness, its use—especially combined with sildenafil (Viagra®) — may encourage unsafe sexual behavior. This increases people’s risk of contracting or transmitting HIV/AIDS or hepatitis.
MDMA increases the activity of three brain chemicals:
- Dopamine — causes a surge in euphoria and increased energy/activity
- Norepinephrine — increases heart rate and blood pressure, which are particularly risky for people with heart and blood vessel problems
- Serotonin — affects mood, appetite, sleep, and other functions. It also triggers hormones that affect sexual arousal and trust. The release of large amounts of serotonin likely causes the emotional closeness, elevated mood, and empathy felt by those who use MDMA Canada.

Other health effects include:
- nausea
- muscle cramping
- involuntary teeth clenching
- blurred vision
- chills
- sweating
